primobolan side effects

The frequency is unknown – according to available data to set the frequency of occurrence was not possible.Violations of the blood and lymphatic system rare: primobolan side effects anemia (including haemolytic), thrombocytopenia, eosinophilia. Disorders of the nervous system Rare: dizziness, headache, paresthesia, peripheral neuropathy ; very rare: sleep disorders (insomnia, “nightmarish” dream), depression, loss or memory loss, blurred vision. violations of the respiratory system, organs, thoracic and mediastinal disorderscommon: upper respiratory tract infection, the frequency is unknown: interstitial lung disease ( . especially with prolonged use), bronchitis, sinusitis Violations of the heart often: atrial fibrillation.

Disorders of the digestive system often: gastritis rare: constipation, abdominal pain, nausea, vomiting, diarrhea, flatulence, pancreatitis. Violations of the liver and biliary tract rare: hepatitis, jaundice, very rarely fatal and non-fatal hepatic failure.

Disorders of the skin and subcutaneous tissue disorders rare: rash, itching skin, alopecia, photosensitivity. Violations of the musculoskeletal and connective tissue disorders rare:myopathy * (including myositis), rhabdomyolysis (with or without acute renal failure), myalgia, muscle cramps, polymyositis, very rare: arthralgia, arthritis, the frequency is unknown: . tendinopathy, possibly with tendon rupture * in clinical trials of myopathy was observed more frequently . in patients treated with simvastatin 80 mg / day, as compared to patients applying the dose of 20 mg / day (1.0% vs. 0.02%, respectively) Violations of the kidneys and urinary frequency is unknown: acute renal failure (due to rhabdomyolysis), urinary tract infection. violations of the genital and breast frequency is not known: erectile dysfunction, gynaecomastia.

General disorders and injection site rarely . weakness Allergic primobolan side effects reactions are rare: angioedema, polymyalgia rheumatica, vasculitis, an increase in the erythrocyte sedimentation rate (ESR), a positive antinuclear antibody titers, facial flushing, lupus syndrome, dyspnea, malaise; Frequency not known: immune-mediated necrotizing myopathy, toxic epidermal necrolysis (Lyell’s syndrome), erythema multiforme, including Stevens-Johnson syndrome. Laboratory and instrumental data rare: increased activity of “liver” transaminases, alkaline phosphatase and creatine kinase in the blood plasma; Frequency not known: an increased concentration of glycated hemoglobin hyperglycemia. The following additional adverse events have been reported with the use of other statins: • Memory loss • cognitive impairment • diabetes. The incidence of diabetes mellitus is dependent on the presence of risk factors (fasting blood glucose concentration of more than 5.6 mmol / L, body mass index greater than 30 kg / m², an increased concentration of thyroglobulin (TG) in blood plasma, a history of hypertension). Children and adolescents (10-17) according to a study duration of 1 year in children and adolescents (boys Tanner stage II and above and girls, at least one year after the first menstrual period), aged 10-17 years, with heterozygous familial hypercholesterolemia (n = 175 ), in the group employing simvastatin, it was similar to the profile of the group, placebo applying safety and tolerability profile. The most frequently reported side effects are upper respiratory tract infection, headache, abdominal pain, nausea. The long-term effects on physical, intellectual and sexual development is not known. At this time (a year after treatment) there is insufficient safety data.

To date, specific symptoms of overdose (maximum dose taken 3.6 g) were detected. Treatment: symptomatic therapy. A primobolan side effects specific antidote is not known.

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