Special patient groups: no need for special dose selection for elderly patients drug. No data on the admission of primobolan results in patients with renal or hepatic insufficiency. As budesonide and formoterol are mainly derived with the participation of hepatic metabolism, the patients with severe cirrhosis of the liver can be expected to slow the rate of excretion of the drug. Children under 6 years: Symbicort Turbuhaler is not recommended for children under 6 years old.
Instructions for proper use turbuhaler :
The mechanism of action turbuhaler: inhalation by the patient through the mouthpiece of the drug enters the respiratory tract. It is necessary to instruct the patient:
• carefully review the instructions for use turbuhaler
• breathe heavily and deeply through the mouthpiece to ensure getting the optimal dose of the drug to the lungs
• never to breathe out through the mouthpiece
• rinse your mouth with water after inhalation maintenance doses to reduce the risk of developing oral mucosal candidiasis and pharynx. It is also necessary to rinse your mouth with water after inhalation for the relief of symptoms in the case of candidiasis of the mucous membranes of the mouth and throat.
The patient may not taste primobolan results or feel the medication after using turbuhaler, due to a small amount of the substance to be delivered.
Symptoms of overdose of formoterol:. Tremor, headache, palpitations
In some cases, it was reported on the development of tachycardia, hyperglycemia, hypokalemia, lengthening , arrhythmia, nausea and vomiting. Can be assigned to supportive and symptomatic treatment.
If necessary, cancel primobolan results turbuhaler due to overdose of formoterol, which is part of a combined drug, should consider the appointment of an appropriate glucocorticosteroid.
In acute overdose of budesonide, even in large doses, is not expected clinically significant effects. In chronic receiving excessive doses can manifest systemic effects of glucocorticoids such as hypercortisolism and adrenal suppression.
Interaction with other drugs
Receiving 200 mg ketoconazole once daily increases in the plasma concentration of oral budesonide (3 mg single dose) with their concomitant use, on average, 6 times. When assigning ketoconazole by 12 hours after administration of budesonide in the plasma concentration of the latter was increased an average of 3 times. Information about such interactions with inhaled budesonide is not, however, expect a noticeable increase in the plasma concentration of the drug. Since the data for recommendations on the selection of doses available, to avoid the above combination of drugs. If this is not possible, the time interval between administration of ketoconazole and budesonide should be maximized. You should also consider reducing the dose of budesonide. Other potent inhibitors of , probably also can significantly increase the plasma concentration of budesonide. Not recommended the appointment of as maintenance therapy and cupping to patients receiving strong inhibitors.
Receptors may attenuate the effect of formoterol. Should not be administered simultaneously with β-blockers (including eye drops) unless required cases.
turbuhaler and quinidine, disopyramide, procainamide, phenothiazines, antihistamines (terfenadine), monoamine oxidase inhibitors primobolan results and tricyclic antidepressants can prolong the interval QTc and increase the risk of ventricular arrhythmias.
in addition, levodopa, levothyroxine, oxytocin and alcohol may reduce the tolerance of the heart muscle to β 2 -adrenomimetikam.
Co-administration inhibitors and drugs with similar properties such as furazolidone and procarbazine, may cause increased blood pressure. There is an increased risk of arrhythmias in patients receiving general anesthesia drugs halogenated hydrocarbons.
In a joint reception and turbuhaler other β-adrenergic drugs may increase the side effects of formoterol.
As a result of .beta. 2 -adrenomimetikov hypokalemia can occur, which may be aggravated by concomitant medication xanthine derivatives, mineral derivatives of corticosteroids or diuretics.
hypokalemia may enhance susceptibility to the development of arrhythmias in patients receiving cardiac glycosides.
There was no interaction primobolan results of budesonide and formoterol with other drugs used to treat asthma.