Absorption of simvastatin high. After oral administration primobolan depot for sale the maximum plasma concentration is reached after about 1.3 – 2.4 hours, and reduced by 90% after 12 hours. It is metabolized in the liver, it has the effect of “first pass” through the liver (hydrolyzed to form an active derivative: a beta – hydroxy acid, found and other active and inactive metabolites). The half-life of the active metabolite is 1.9 hours.
Excreted mainly with faeces (60%) in the form of metabolites. About 10 – 15% is excreted by the kidneys in an inactive form.
- Primary Hypercholesterolemia (IIa and type IIb) when poor diet low in cholesterol and other non-drug interventions (exercise and weight reduction) in patients with an increased risk of coronary atherosclerosis;
- combined hypercholesterolemia and hypertriglyceridemia Coronary heart disease: for the prevention of myocardial infarction, to reduce the risk of death, reducing the risk of cardiovascular events (stroke or transient ischemic attacks), slowing the progression of atherosclerosis of the coronary vessels, reducing the risk of revascularization procedures.
The drug is contraindicated for use in case of hypersensitivity to the active substance or other components of the preparation, with active pathological process in the liver, in children under 18 years. The drug is contraindicated in pregnant women.
- Generally Simvakard well tolerated. Side primobolan depot for sale effects associated with taking the drug is usually not expressed and are temporary in nature. The most common side effects observed with the digestive system: dyspepsia, abdominal pain, nausea, constipation, diarrhea, metiorizm. In rare cases, a feeling of weakness, dizziness, headache, pancreatitis, signs of peripheral neuropathy, convulsions, anemia. Very rarely observed side effects liver: hepatitis, jaundice, possible temporary increase in liver transaminases. In extremely rare cases, myopathy, rhabdomyolysis. In the case of pain or increased sensitivity of skeletal muscles, muscle weakness should stop taking the drug and seek emergency medical attention.
Treatment: Induce vomiting, take activated charcoal. Symptomatic therapy.
INTERACTION WITH OTHER DRUGS
When odnovrmenno use of simvastatin with cytostatics, fibrates, nicotinic acid, erythromycin or clarithromycin, itraconazole. HIV-protease inhibitors (indinavir, ritonavir, nelfinavir), an antidepressant nefazodone increased risk of myopathy. Simvastatin enhances the action of anticoagulants, increases the level of digoxin concentrations in plasma.
Be used with caution on patients with liver disease, prone to allergic reactions, alcohol abuse, low or high tone of the skeletal muscles of unknown etiology, renal failure. Before and during treatment with recommended control of liver function. Use of the drug Simvakard does not negatively affect activities requiring increased attention and speed of mental and motor responses, such as in persons primobolan depot for sale who control transport serving the machine when working at height, etc.